Common use

Stalevo is a combination medication used to treat Parkinson’s disease by managing its motor symptoms such as tremors, stiffness, and slowness of movement. It contains three active ingredients: Levodopa (converts to dopamine in the brain), Carbidopa (prevents early breakdown of Levodopa), and Entacapone (prolongs Levodopa’s effect by inhibiting COMT enzyme). This triple-action helps improve muscle control and reduce "off" episodes. Stalevo is used when Levodopa/Carbidopa alone no longer provide sufficient symptom control.

Dosage and direction

Stalevo is taken orally, usually three to four times a day, as directed by your neurologist. Each tablet contains a fixed dose of all three components and should be swallowed whole without crushing or chewing. The dosage is carefully adjusted based on the patient's previous Levodopa/Carbidopa regimen. It should be taken at regular intervals, with or without food.

Precautions

Before using Stalevo, inform your doctor if you have a history of heart disease, glaucoma, liver problems, or psychiatric disorders. Use caution when driving or operating machinery, as the medication may cause drowsiness or sudden sleep attacks. Patients should be monitored for signs of hallucinations, compulsive behaviors, or dopamine dysregulation syndrome. Avoid sudden discontinuation, as it may lead to serious withdrawal symptoms.

Contraindications

Stalevo is contraindicated in individuals with narrow-angle glaucoma, pheochromocytoma, or known hypersensitivity to any of its ingredients. It should not be taken by patients receiving non-selective MAO inhibitors, as it may cause a dangerous increase in blood pressure. It is not recommended for individuals with severe liver disease. Always consult a specialist before initiating treatment.

Possible side effect

Common side effects include nausea, diarrhea, dizziness, involuntary movements (dyskinesia), and hallucinations. Some patients may also experience confusion, insomnia, or low blood pressure when standing (orthostatic hypotension). Rare but serious side effects include neuroleptic malignant syndrome (NMS) and rhabdomyolysis. Inform your doctor if unusual mental or physical symptoms occur.

Drug interaction

Stalevo may interact with MAO inhibitors, antipsychotics, iron supplements, and medications affecting dopamine metabolism. Combining it with certain antidepressants or blood pressure medications may increase the risk of side effects. Inform your doctor about all prescription, over-the-counter, and herbal products you are using. Avoid alcohol as it may worsen side effects like dizziness or drowsiness.

Missed dose

If you miss a dose, take it as soon as you remember unless it’s almost time for the next one. Do not double up to make up for a missed dose. Skipping doses may result in worsening of Parkinson’s symptoms. Maintain a regular dosing schedule to ensure consistent symptom control.

Overdose

An overdose of Stalevo can cause severe involuntary movements, confusion, irregular heartbeat, or muscle breakdown. Seek immediate medical attention if overdose is suspected. Hospitalization and symptomatic treatment may be required. Do not exceed the prescribed daily dosage.

Storage

Store Stalevo at room temperature (15–30°C / 59–86°F) in a dry place away from moisture and heat. Keep the bottle tightly closed when not in use. Do not use after the expiration date printed on the packaging. Keep out of reach of children and pets.

Disclaimer

We provide only general information about medications which does not cover all directions, possible drug integrations, or precautions. Information at the site cannot be used for self-treatment and self-diagnosis. Any specific instructions for a particular patient should be agreed with your health care adviser or doctor in charge of the case. We disclaim reliability of this information and mistakes it could contain. We are not responsible for any direct, indirect, special or other indirect damage as a result of any use of the information on this site and also for consequences of self-treatment.